Stratified Semiparametric Regression Analysis of Partly Interval Censored Failure Time Data with Missing and Mis-Measured Longitudinal Covariates

Doctoral Candidate Name: Gang Cheng
Program: Mathematics (Applied)
Defense Date and Time: April 4, 2025 – 1:30 PM
Defense Location: Fretwell 340Q
Committee chair’s Name: Dr.Yanqing Sun
Committee Members: Dr.Qingning Zhou, Dr.Yinghao Pan, Dr.Asissis Nasipuri
Abstract:

Partly interval-censored failure time data are common in clinical and epidemiological studies, where the failure time of interest is either exactly observed or known to lie within a specific interval. Additionally, two-phase sampling designs are often employed to measure covariates for a subset of participants, reducing study costs. This paper addresses regression analysis of partly interval-censored failure time data under stratified semiparametric transformation models, incorporating time-dependent covariates subject to: (i) missingness due to two-phase sampling and (ii) measurement errors during observation. We propose a maximum weighted likelihood estimation method and develop an EM algorithm for implementation. A weighted bootstrap approach is introduced for variance estimation, and the asymptotic properties of the proposed estimator are established. Extensive simulation studies demonstrate the method’s satisfactory finite-sample performance, and its practical utility is illustrated through an application to data from the HIV prevention trials HVTN-703/HVTN-704.