This dissertation addresses critical aspects of traffic safety, focusing on novel approaches for weather-related crash prediction—a significant concern in the transportation field. It is divided into three interconnected studies: geospatial risk mapping of weather-related crashes, addressing data imbalanced in machine learning for weather-related crash severity analysis, and analytics for future weather-related crash prediction. In the first study, the dissertation advances a novel approach to hotspot mapping by developing a spatio-temporal cube that incorporates both the spatial and temporal dimensions of crash data, providing a dynamic and comprehensive analysis of crash hotspots. In the second study, the dissertation tackles the challenge of imbalanced data, which can bias machine learning model outputs, making them less adept at predicting crash severity. By extending methods such as Synthetic Minority Over-sampling Technique (SMOTE) and Adaptive Synthetic Sampling (ADASYN), the dissertation evaluates the effectiveness of these methods in datasets with a prevalence of nominal predictors, aiming to enhance the predictive accuracy of machine learning models for crash severity. Lastly, the dissertation proposes the use of Spatially Ensembled ConvLSTM algorithm for predicting a weather-related traffic crash. This approach aims address the limitations of traditional predictive models by leveraging the ability of LSTMs to retain relevant information over extended time frames across different heterogenous spaces. The proposed technique was compared with existing methods to test if it outperform conventional predictive models and the standard ConvLSTM in accuracy.