Perioperative Care Practices and Outcomes of Patients Taking Long-Acting Glucagon-Like Peptide 1 Receptor Agonists at a Level 1 Trauma Center

The perioperative care practices related to the management of patients taking long-acting Glucagon-Like Peptide 1 Receptor Agonists (GLP-1 RAs) are a relatively new anesthetic concern, as these medications have recently become increasingly popular. Surgical-related consequences of these medications include gastrointestinal side effects, pulmonary aspiration, longer hospital stay, and mortality. Through the examination of clinical practices and patient outcomes at a level 1 trauma center, this quality improvement project sought to provide recommendations for perioperative care practices for adult patients taking long-acting GLP-1 RAs. The clinical question was: Among adult patients taking long-acting GLP-1 RAs at a level 1 trauma center, what are the perioperative care practices being implemented and how do these affect patient outcomes while receiving anesthesia during surgery? Data were collected via a retrospective chart review of 56 charts, six of which were excluded due to being emergent cases. Data were analyzed using descriptive and correlational statistics. In addition, an anonymous survey was completed by 47 anesthesia providers to provide further descriptive information about perioperative care practices and outcomes. Findings showed a lack of POCUS use, inconsistent practices noted in chart review and survey, and providers desiring for further education on this topic, especially in regard to adequate medication hold time. Continued research and projects on this topic are imperative. Recommendations include provider education, implementation of POCUS in the preoperative setting, and creation of a clear policy for these patients that will help guide safe practice.